New insights into the regulation of the SNC1 resistance gene (IPS2, SPS), https://sco.lt/5Su5Am
To defend against pathogens (bacteria, fungi, etc.), plants have a complex immune system composed of two main lines of defense: Pattern-Triggered Immunity (PTI) triggered by the recognition of Pathogen-Associated Molecular Patterns (PAMPs) at the plasma membrane, and Effector-Triggered Immunity (ETI) triggered by the detection of microbial effectors within plant cells. Long considered independent, recent studies show that PTI and ETI interacts closely. For instance, the PAMP-induced Mitogen Activated Protein Kinases 3 and 6 (MPK3/6) are involved in the induction of certain immune genes, such as the SNC1 gene, coding for receptors of effectors. However, the underlying regulatory mechanisms remain largely unknown.
In a research article published in Scientific Reports, researchers from the STRESS team at IPS2 have shown through genetic approaches that the chromatin remodeling factor 5 (CHR5) acts downstream of MPK3/6 to promote the expression of SNC1. The authors also showed that, while CHR5 does not regulate the abundance or activity of MPK3/6, the combination of autoimmune gain-of-function mutants for MPK3 and SNC1 leads to a strong synergistic effect. Overall, the results obtained identify a new MPK3/6-CHR5-SNC1 signaling module and thus contribute to a better understanding of the links between PTI and ETI.
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