Structural and molecular immunology and protein biophysics at the University of Notre Dame. T cell receptors, MHC proteins, specificity, and cross-reactivity. Plus drums, odd time signatures, Iron Maiden, and much Rush. Opinions mine alone.
bmblab.nd.edu
Baker Lab @ Notre Dame
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Congratulations to super star Jiaqi Ma and the rest of the lab. An ongoing part of our exciting collaboration with Chris Klebanoff and team @klebanofflab.bsky.social - important clinical implications for targeted T cell therapy, vaccines, and transplantation.
New work from the lab showing how micropolymorphisms in HLA superfamilies can dramatically impact TCR specificity, even in the absence of changes to static structure or peptide binding. The secret's in how the peptides move around - or not, in the case of A0302 vs A0301. www.pnas.org/doi/full/10....
Dive bar tour begins (and ends?) in a week and half! Maybe we should decide on a tour poster.
I know paylines aren't a thing anymore, but I think this is ok...? T cell targets in transplantation, your time is coming! Thank you nice reviewers, even #3 I suppose!!! 😀
@gezelter.bsky.social
Short break from grant writing. New rehearsal space coming together.
Huge congratulations to Chukwunalu "Chuks" Chukwuma for successfully defending his PhD thesis on interrogating the specificity of alloreactive T cells and the implications for organ transplant rejection! Another newly minted structural immunologist setting out to make the world a better place.
A Perspective discusses challenges in macromolecular ensemble prediction and the methodological advances that are needed. @stephanieaw.bsky.social
www.nature.com/articles/s41...
Lab people: "Hey, look at all these cool AI models, AlphaFold, Chai, Boltz, gazillion models per week, blah blah, cool new relationships, experiments schmeriments."
Me, looking at one model: "Huh, arginine and tyrosine in the same volume of space, right where the receptor would sit. Nifty."
Sigh.
