Online Now: STING unlocks CD4⁺ T cell immunity in pancreatic cancer
Pancreatic ductal adenocarcinomas (PDACs) are lethal cancers resistant to immunotherapies. In this issue of Cancer Cell, Kureshi et al. show that combining checkpoint blockade with STING-mediated innate immune stimulation unlocks cDC2-driven CD4+ T cell immunity in mice, promoting PDAC immune control. This cellular axis may be exploited for PDAC therapy.
