Cancer stem cells orchestrate immune evasion through extracellular vesicle-mediated non-canonical signaling pathways
Tumor cells evade anti-tumor immunity by reprogramming TME. Fan et al. uncover that cancer stem cells of TNBC drive regulatory T cells differentiation and expansion via a paracrine signaling mediated by TSPAN8-enriched extracellular vesicles (EVs), independent of canonical EV cargo internalization. Neutralizing EVs-TSPAN8+ enhances anti-PD-1 efficacy in TNBC preclinical models.
