Tissue tension fosters macrophage-driven lipid peroxidation-induced DNA damage
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Hayward et al. show that stromal fibrosis drives epithelial STAT3-mediated chemokines to recruit macrophages. Macrophages respond to elevated tissue tension by undergoing lipid peroxidation, generating aldehydes that induce epithelial DNA damage and promote tumor progression. This study connects fibrosis and inflammation to DNA damage in cancer risk and progression.
