A conserved re-epithelialization program underlies malignancy in pancreatic ductal adenocarcinoma
Zhuo et al. identify a conserved cutaneous re-epithelialization program, MP10 that underlies pancreatic cancer malignancy. Distinct from EMT, this program is driven by the transcription factor FOSL1 during the transition from precursor lesions. Wound-like CTHRC1high myCAFs promote FOSL1 expression through EGFR signaling, revealing targetable tumor-stroma crosstalk in PDAC progression.
