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by @danabra.mov
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by @jimpick.com
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Exciting work by @drtesutherland.bsky.social! #ScienceImmunology uncovers chitinase like proteins as key drivers of airway ECM remodeling, blocking Ym1 can reverse it! #Immunology #RespiratoryResearch #SciOpen #TUP
8mo
SciOpen
Extremely happy to see our work out in #ScienceImmunology. We show allergen-induced ECM remodelling occurs independently of IL-13 or IL-17 driven inflammation. Rather chitinase-like proteins drive airway ECM accumulation & inhibition of Ym1 can remarkably reverse it. www.science.org/doi/10.1126/...
8mo
Allergic airway matrix remodeling occurs independently of IL-13 and IL-17A and is driven instead by chitinase-like proteins.
www.science.org
Allergen-induced airway matrix remodeling in mice can be prevented or reversed by targeting chitinase-like proteins
Tara Sutherland