New paper out in @jimd-editors.bsky.social. In children with CLN2 disease — a form of childhood dementia — we show that brain atrophy on MRI tracks each child's clinical decline, making brain scans a promising tool to monitor treatment of this devastating, ultra-rare disorder. #pediatrics
Neuronal ceroid lipofuscinosis type 2 (CLN2) disease, a lysosomal storage disorder, causes early childhood psychomotor regression, vision loss, seizures, and rapid progressive gray matter loss. Howev...
