Beautiful discovery by the Huber and Kubicek labs and a wonderful example of using targeted protein degradation to probe novel non-catalytic functions.
Jordan Meier
New in @science.org 🧬
What if an enzyme you thought you knew turned out to control metabolism in a completely new way?
We found that NUDT5 acts as a molecular handbrake on purine synthesis, reshaping how cells make DNA building blocks and respond to cancer drugs.
www.science.org/doi/10.1126/...
Folate metabolism is intricately linked to purine de novo synthesis through the incorporation of folate-derived one-carbon units into the purine scaffold. By investigating chemical and genetic depende...
