Research Spotlight
#OPCs act as glucose-sensitive biosensors during brain development. Sauma et al. show that ACLY links glucose metabolism to histone acetylation, regulating OPC proliferation and differentiation. A potential target for #myelin repair.
https://doi.org/10.1038/s41593-026-02263-7
The authors identify glucose-derived conversion of citrate to acetyl-CoA upstream of histone acetylation as modulating the regional dynamics of oligodendrocyte progenitors, with extranuclear acetyl-CoA from other sources being used for myelination.
