Lesion-remote #astrocytes drive microglia-mediated white matter repair. McCallum et al. show that CCN1+ astrocytes reprogram #microglia for myelin debris clearance after CNS injury, promoting recovery.
https://www.nature.com/articles/s41586-025-09887-y
#WhiteMatter #Demyelination #Neuroimmunology
After spinal cord injury, lesion-remote astrocytes acquire heterogeneous, spatially restricted reactivity states that shape neuroinflammation, neural repair and neurological recovery.
