Evolutionary Biologist
Using Experimental Evolution to look at mutational biases in bacteria!
Research Gate Profile: https://t.co/xhw63knBCj
email: [email protected]
Jake Barber
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Check our new paper which I had the privilege to write with @kostchristian.bsky.social published in PNAS!
Fresh news on de novo genes! Happy to present our latest work published in Nature communications: www.nature.com/articles/s41...
Keywords not in specific order: intergenic ORFs, de novo genes, GC content, foldability, genetic code, ancestral sequence reconstruction and more :)
Spatial structure: Shaping the ecology and evolution of microbial communities
@femsjournals.bsky.social Microbiology Review by @marcelbaecker.bsky.social et al
from @bedutilh.bsky.social @bramvandijk.bsky.social
academic.oup.com/femsre/advan...
This has finally been published in Nature Communications! Please check it out if you are interested in population genetics, antibiotic resistance and mutation biased adaptation :)
www.nature.com/articles/s41...
New paper by Saskia Wilmsen and me just came out BioEssays:
A new classification framework to understand evolutionary transitions in individuality
Please find the OA paper here:
onlinelibrary.wiley.com/doi/10.1002/...
Having just finished my MCSA Fellowship with him, I would really encourage those looking to do a postdoc in microbial adaptation to check out Alex Couces lab in Madrid. Alex is a gifted researcher, and Madrid is a wonderful city to live in :) Details in link below:
evoldir.net/brian/evoldi...
You have heard of the gut microbiome but what do we know about plant microbiomes? Christopher Blake & colleagues examined the bacteria in the rhizosphere of Canola and suggest scope for better design interventions that support sustainable crop production. doi.org/10.1016/j.bc...
evoldir.net
Storme De Scally et al describe how genomic and biological characterisation of bacteriophages help us better understand bacteria-phage ecological and evolutionary dynamics in natural and synthetic communities. @mikejmcd.bsky.social @jeremyjbarr.bsky.social www.sciencedirect.com/science/arti...
Our study comparing promoter existence and emergence in random vs genomic DNA is finally published!!!
TLDR: the E. coli genome has more promoters than random DNA (even in intergenic regions), and promoters emerge ~3x more readily from random DNA than genomic DNA. (1/2)
Ákos T Kovács
Jake Barber
Jake Barber
Anne Lopes
Shryli Shreekar
Our work characterizing how mutational bias is influenced by the local sequence context beyond trinucleotides is out now @pnas.org! We also showed which motifs are most prone to mutations caused by strand misalignment, revealing several new hotspots! 🧬
www.pnas.org/doi/10.1073/...
Promoters emerge three times more readily from random DNA than from genomic DNA.
Abstract. Most microbes grow in spatially structured communities, and this profoundly shapes their ecology and evolution. At the microscale, short interact
Classifying biological entities based on whether and how the two fundamental aspects physiological and evolutionary components are represented yields six types of structural organization. The resulti...
@shrylishreekar.bsky.social and me wrote a commentary on Chunhui Hao's and @stuwest.bsky.social et al.'s recent paper
"Cooperation and the evolution of bacterial niche breadth"
in PNAS.
Please find our commentary here:
www.pnas.org/doi/10.1073/...
Christian Kost
Adaptation is assumed to proceed by survival of the fittest. The study shows that mutation bias can drive adaptation via survival of the likeliest, steering bacteria along divergent paths to resistanc...
New pre-print is finally out! This is the first project from my postdoc with Alejandro Couce, looking at how mutation-bias influences adaptation across large population sizes, and how this may have real world consequences. Really happy with how this turned out :)
www.biorxiv.org/content/10.1...
