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Provocative: www.nature.com/articles/nn1... I feel the same way about anesthesia in sensory neuroscience... probably just as many confounds of awake recordings as in anesthetized, just different problems. But less clear than it might seem at first pass about which one is "natural"
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Nature Neuroscience - In praise of artifice
www.nature.com
In praise of artifice - Nature Neuroscience