Professor @ Goethe Uni & IBC2-GU, Co-founder of Vivlion. #BerlinER #FrankfurtER
Manuel Kaulich
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A fantastic line up of speakers.
Hope to see many of you in wonderful Mainhatten (Frankfurt).
Congrats to first author @maxbillmann.bsky.social and the entire team for this amazing #PERTomics effort. A prime example of hashtag#PERTomics.
www.cell.com/cell/fulltex...
#PERTomics, the systematic functional perturbation of genes and quantification of subcellular, cellular, and organismal responses. To functionally annotate uncharacterized genes, build genetic interaction maps, identify drug dependencies and synergies, and understand polygenetic biology.
So great to this preprint out.
It was/is such a pleasure to work with this fantastic team.
Congratulations to all of you!
Happy to share another paper from the lab.
While KEAP1 is often mutated in aggressive lung cancer, its loss can paradoxically suppress tumor growth in certain contexts by inducing Nrf2-driven reductive stress.
link.springer.com/article/10.1...
Out now on bioRxiv! 🧬🖥️
Dewi Moonen, @anniquec.bsky.social and a team led by Lars Steinmetz and Daniel Schraivogel at EMBL have mapped the downstream regulatory networks of thousands of immune disease-relevant variants in CD4+ T cells
www.biorxiv.org/content/10.6...
DNA guides instead of RNA?!
A CRISPR-Cas12a system flips the script, using DNA guides to target RNA.
🔬 Enables direct RNA detection + knockdown
🧬 Reveals a distinct activation mechanism
⚙️ Expands the toolbox for programmable RNA control
Big step for CRISPR versatility.
www.nature.com/articles/s41...
Manuel Kaulich
Manuel Kaulich
Very proud to see this work out on bioRxiv. Using genome-scale TAP/Perturb-seq we mapped the function of immune-disease variants to target genes and regulatory cascades. Have a look at the 🧵from @anniquec.bsky.social for more info!
Manuel Kaulich
www.biorxiv.org
Manuel Kaulich
Manuel Kaulich
Manuel Kaulich
Open Targets
How do immune disease-relevant variants rewire gene regulation in CD4+ T cells?
In a collaboration led by Daniel Schraivogel and Lars Steinmetz at @embl.org, we combined two large-scale CRISPRi screens (4.1M cells) to map the downstream cascades of thousands of SNPs.
Video
Stegle Lab
🧬 How do immune disease-relevant variants affect gene regulatory networks in CD4+ T cells?
🧪🖥️ We coupled two large-scale CRISPRi screens (>4M cells) to map the downstream cascades of thousands of SNPs
More details in the thread below 👇 or in the article 📖 on biorxiv tinyurl.com/CD4screens
Annique Claringbould
Excited host @hohmannulrich.bsky.social from @imbmainz.bsky.social, along with @manuelkaulich.bsky.social
Date: 07.04.2026
Time: 15:00
Venue: Haus 22 Seminar Room 1. (S22-1)
Title: ‘Mechanistic insights into nuclear mRNA export and degradation’
@goetheuni.bsky.social @cpi-exstra.bsky.social
