To activate plant immunity, NLR receptors such as SUMM2 form resistosome complexes, which act as Ca2+-permeable plasma-membrane channels. Work @nature shows how SUMM2 and its associates assemble into even higher-order clusters to initiate cell death.
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SUMM2, a coiled-coil NLR, promotes the assembly of higher-order resistosome clusters to initiate cell death in plants.
