We develop tools for imaging cellular spatiotemporal regulation of metabolism in the Department of Chem & Biochem @ UCLA
Schmitt Lab @ UCLA
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Our efforts to engineer Meteor are led by amazing grad student Katarina, with assistance by Arnav, Megan, and Naia, and in vivo imaging was done in collaboration with Ryo Higuchi-Sanabria and his postdoc Gilbert at USC. It’s always fun when we can collaborate with our friends across town!
The Schmitt Lab will be at ASBMB 2026! Check out our posters and learn about what the Schmitt Lab has been up to!
The Schmitt Lab is at ASBMB! Check out our posters over the next few days!
🍾 Congrats to @charlotteek.bsky.social the 7th graduate student to advance to candidacy in the Schmitt Lab! Charlotte passed with flying colors!
✨New Review✨ Coordinated by Mia Sung, we contributed to a new review about non-invasive imaging of single cell dynamics! Written by leaders in the field, this comprehensive review discusses how we can measure single cell dynamics, with a section on metabolite biosensors. www.cell.com/trends/cell-...
Today our paper reporting on our new PINK1 biosensor is out! We are very excited about the future use of this tool to study PINK1 biology. Plasmids are available on Addgene & we are preparing a protocol paper. pubs.acs.org/doi/10.1021/...
☄️New biosensor!☄️ We present Meteor, our GFP-based methionine optical reporter, which can be used to measure methionine dynamics across scales, from subcellular to organisms like C elegans! Plasmids will be deposited with Addgene. www.biorxiv.org/content/10.6...
Today I received a departmental award for excellence in inclusion & mentoring! It really means a lot to me to receive this award, and that all my efforts to be an effective mentor to my trainees, at UCLA, and beyond are recognized. Thank you so much to my lab members who nominated me for this award.
🎇PINK1-SPARK: A phase separation-based biosensor for PINK1 activity! Find the plasmids here: www.addgene.org/browse/artic...
📚New review! Led by our amazing post-bac Arnav, we have put together a history of AMPK biosensors & highlighted some cool use cases! We hope this review will help broaden the adoption of biosensors in the field & increase our understanding of dynamic AMPK activity. portlandpress.com/biochemj/art...
Methionine is an essential amino acid, used for protein synthesis, redox homeostasis, and methylation reactions throughout the cell. However, the compartmentalized dynamics of methionine have remained...
