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We discuss how single-molecule force spectroscopy reveals chromatin as a mechanical medium that is written, read, and reshaped by DNA, histones, TFs, and architectural proteins.
Very happy we could contribute to this interesting study led by Natalio Krasnogor. Congrats to all the authors! www.nature.com/articles/s41...
1mo
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Ariel Kaplan
Ariel Kaplan
Why can't we explain enhancer action despite 2 decades of chromosome conformation technologies? 😬 Our new study spearheaded by Leonid Mirny's group points to a flaw in our assumptions, and to a solution from physical principles By @timothyfoldes.bsky.social 💻& @karissalhansen.bsky.social 🧪 🧵👇
1mo