In human pluripotent stem cells, many enhancers, which will become active later in development, are already marked with poised (bivalent) chromatin features and form chromosomal contacts with gene promoters.
This story adds to our understanding of when, how and why this happens.
Led by Marina Nocente and initiated by Monica Della Rosa in the lab, this has been a great collaboration with Maria Rostovskaya and Peter Rugg-Gunn's team at Babraham.
A new study tracks how cells prepare gene regulatory decisions that will define their fate during the earliest stages of human development and highlights how the genome’s 3D structure helps shape cell identity and could offer clues to how developmental disorders arise 🧬
Mikhail Spivakov
Mikhail Spivakov
New research tracks how cells prepare gene regulatory decisions that will define their fate during the earliest stages of human development. The study reconstructs a timeline of chromosome folding tha...
