Research in the Developmental Biology Unit focuses on exploring the rich diversity and complexity of living systems, taking into account their natural context.
EMBL DB unit
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✨At this week's DB unit seminar @embl.org, Serena Flori @serenaflori.bsky.social, a postdoc in the Vincent group @floravincent.bsky.social, presented her work on the structural basis of diatom responses to marine heatwaves. You can also check out her paper here: www.cell.com/current-biol...
EMBL DB unit
🔥New paper from the Ikmi group @aikmi.bsky.social @embl.org who discovered a "secret" second valve in Nematostella vectensis that acts as a pressure release system. Congratulations to all the authors 🥳
✨ At this week's DB seminar @embl.org, Jlenia Vitale, a postdoc in the Petridou group @nicolettapetridou.bsky.social, presented her work on the interplay between cell-cell adhesion and mitochondrial activity during tissue phase transitions in Zebrafish and killifish embryos 🐟🔬#DevelopmentalBiology
✨ This week, Nikki Cannon, a PhD student in the van Gestel group @jordivangestel.bsky.social, presented her work on creating an end-to-end assembly and annotation pipeline for Dictyostelids at the DB unit seminar @embl.org
🔥 Fantatstic work by Antonella Ruggiero and colleagues @embl.org and @szndohrn.bsky.social that opens new doors to understanding the decision-making mechanisms of phytoplankton and the hidden complexity of single-celled life in our oceans #Diatoms #DevelopmentalBiology #SingleCellRNA #Phytoplankton
🔥New work from the Crocker group @justinmcrocker.bsky.social @embl.org on the mechanistic and evolutionary basis of dominance from cis-regulatory variation in Drosophila Congratulations to Noa @ottilie.bsky.social and all the authors 🥳
✨ At this week's DB Unit Seminar @embl.org , Levin Riedel, a phD student in the Ikmi group @aikmi.bsky.social, presented his work on the effects of neuropeptides on morphogenesis and development of Nematostella vectensis larvae and polyps.
EMBL DB unit
EMBL DB unit
EMBL DB unit
EMBL DB unit
EMBL DB unit
EMBL DB unit
Many thanks @nicolettapetridou.bsky.social from @embl.org Heidelberg for visiting us @centuri-ls.bsky.social and giving a truly exciting talk on cell division timing and phase transition during embryogenesis 🤩! Developmental biology is really cool 😎
Here the published version of our work on uncoupling different types of tissue phase transitions during development!
Find out more on how contact surface tension-driven rigidity transitions trigger tricellular junction formation and initiate epithelial organization!
@natphys.nature.com
Thomas Lecuit
Excited to share my first preprint from my PhD w/ @justinmcrocker.bsky.social. We show that cell type-specific regulatory dominance promotes robustness and evolutionary innovation through interallelic transcriptional hubs, potentially expanding the mutational paths available to diploids. (1/18)
Glad to see this out in its final form!
www.nature.com/articles/s41...
What changed since the preprint? Wonderful experiments disentangling the effect of receptor binding vs tissue porosity on Nodal diffusion, plus one of the smoothest review experiences! Thanks @natcellbio.nature.com & reviewers 🙏
Autorino et al. report a feedback loop between Nodal signalling and tissue phase transitions in zebrafish embryos. Nodal alters adhesion, triggering tissue rigidification and reduced porosity, which l...
⚡ Our paper is now out in @natphys.nature.com !
This version now includes a detailed molecular characterisation of the optogenetic perturbations, new insights on the relevance of tricellular junctions for tissue morphology, and beautiful light-sheet timelapses. 🔬
www.nature.com/articles/s41...
Noa Ottilie Borst
Interallelic cis-regulatory dominance promotes robustness and evolutionary innovation https://www.biorxiv.org/content/10.64898/2026.03.17.712157v1
