Cell Biology and Epigenetics https://www.bio.tu-darmstadt.de/fachbereich_01/personen/bio_kontakt_details_3200.de.jsp
Cardoso lab
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Proud moment for the Cardoso Lab: LEAF Gold 2025 🥇 awarded for our sustainability practices in cell biology & epigenetics research. From Silver in 2024 to Gold in 2025 — and we're not stopping here. Greener labs, better science. 🌱 #LEAF #SustainableLabs @tuda.bsky.social @sfb1361.bsky.social
New in Nucleic Acids Research!
MBD2 forms liquid condensates that organize heterochromatin and control histone acetylation. Combined proteomics + AI predictions reveal how phase separation regulates chromatin states. MBD2 recruits HDACs, excluding HATs.
doi.org/10.1093/nar/...
It was an absolute delight to attend the DNA damage and repair meeting at the SFB 1361 Conference.
Our students showcased their poster presentation and were thrilled to receive the prestigious best poster prize. Congratulations to all of them! 🎉
@imbmainz.bsky.social
MeCP2driven chromatin organization controls nuclear stiffness during neuronal differentiation. UsingAFM, we show heterochromatin clustering increases nuclear mechanics, disrupted by Rett mutations-severity correlates with stiffness defects, not gene expression.
www.nature.com/articles/s42...
Our new work in EMBO Reports! 🧬
H3K36me3 enriches at pericentromeric heterochromatin BEFORE replication, regulating its timing. H3K36me3 loss disrupts satellite transcription and delays replication.
Forward-strand MajSat RNA controls replication timing—ncRNAs as key regulators!
cardoso-lab.org
A new way to watch chromatin moving in living stem cells as they become neurons and what we saw was striking. Chromatin literally slows down as cells commit to their fate.
It's like watching cells physically lock in their identity by constraining their chromatin.
cardoso-lab.org/pages/public...
Congratulations to Dr. Maruthi Kumar Pabba on successfully defending his PhD! What an incredible achievement! Wishing you all the best as you embark on this new chapter!! 👏🎉 #PhDLife #Congratulations @tuda.bsky.social
🧬⚡Your sunscreen is only half the story
We show that near-infrared light makes UV damage WORSE. nIR loosens DNA packaging, creating a repair traffic jam that increases breaks. We are ignoring the invisible majority of solar radiation that hacks DNA repair.
doi.org/10.1038/s415...
@tuda.bsky.social
New review in NAR!
We connect the two halves of the DNA replication field — single-cell microscopy and genome-wide sequencing to show how each method’s strengths build one picture: from DNA fibers → replication foci → origin & timing maps.
đź”— doi.org/10.1093/nar/gkag550
@narjournal.bsky.social
@sunil-k-pradhan.bsky.social talks regarding the role of H3K36m3 epigentic mark on DNA replication progression during his time in our lab.
@fnucleosome.bsky.social
Here is the link
Register for the seminar through this recurring link: us06web.zoom.us/webinar/regi...
Cardoso lab
Cardoso lab
Cardoso lab
Abstract. Genome replication is without doubt the most complex and critical activity of all living cells. Any error may not only affect the cell itself but
Scientific Reports - Exposure of cells to near-infrared irradiation relaxes chromatin compaction and facilitates recognition of cyclo-butane pyrimidine dimers
