Protein Biochemist and Molecular Biologist | DNA break repair in the context of chromatin | PhD student @gerlichlab.bsky.social
Mustafa Alaabo
Congratulations to @mfdspicer.bsky.social and all co-authors on this awesome work 🥳🤩
I'm happy to have made a tiny contribution to the paper
Mustafa Alaabo
SMC and recombination enthusiasts: we updated our work describing the loop extrusion properties of budding yeast condensin and its function in biasing donor usage for mating-type switching. Lots of cool new data, check it out!
www.biorxiv.org/content/10.1...
New preprint out!🧬 How do cells keep replicated sister chromatids linked for DNA repair while folding 3D loops for gene expression? Extrusion folds DNA but separates sisters, while cohesion connects them, risking mutual interference. How do they coexist?🧵👇
🔗 doi.org/10.64898/2026.05.02.722390 1/6
doi.org
1/New preprint just dropped! 🔥🔥 We investigate how the genome is destroyed in apoptotic cells in a way that prevents DNA fragments from spreading beyond the dying cell 🧬⚰
Done here at @imbavienna.bsky.social & in the super @rcollepardo.bsky.social & Rosen labs:
www.biorxiv.org/content/10.6...
Aurele Piazza
Gerlich Lab
Transcription and recombination are two universal DNA-dependent processes, but how they are coordinated remains largely unknown. Here we characterized transcription-recombination priority rules in yeast. 🧵 www.embopress.org/doi/full/10....
1/ New preprint alert!
In collaboration between the Rosen, Redding, Collepardo-Guevara & Gerlich labs, we uncover a surprising principle of chromosome organisation: electrostatic repulsion positions centromeres at the chromosome surface during mitosis.
🔗 doi.org/10.1101/2025...
www.biorxiv.org
if i were a better person i would do a tweetorial on our recent paper - but, hey, read the paper. its right there, waiting for you. #Giantvirus #histones are cool! their #nucleosomes are cool. check it out.! thats the tweetorial.
rdcu.be/exXBX
Gerlich Lab
Check out this new review (with animations, natch) of mechanisms of licensing origins of DNA replication - a wonderful (and continuing!) collaboration with Bruce Stillman @cshlnews.bsky.social and John Diffley @crick.ac.uk! www.nature.com/articles/s41...
During cell division, chromosomes reorganise into compact bodies in which centromeres localise precisely at the chromatin surface to enable kinetochore-microtubule interactions essential for genome se...
doi.org
Aurele Piazza
Video
Gerlich Lab
Congratulations to Mustafa Alaabo, PhD student in Daniel Gerlich’s lab, who was awarded a competitive fellowship by the Boehringer Ingelheim Fonds for his research on DNA repair by homologous recombination.
Apply to the scientific programmer/bioinformatician position at IMBA: https://www.oeaw.ac.at/imba/career-education/open-positions/scientific-programmer-bioinformatician-gerlich-lab
#research #jobs #europe #biology
