How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller?
Excited to share our latest work in @science.org on a new small polymerase.
1/n
The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...
Thanks to the Nature team for digging into this. Apportionment is one of those inside-baseball issues that I hoped never to need to learn about... But here was are.
RIP Brandon Clarke. So sad.
Jamie Raskin not only graduated from Harvard with his JD, (editor of the Harvard Law Review)...he is so dedicated to our country and our constitution that this man BURIED HIS SON, came into work the next day to experience an insurrection, and started writing articles of impeachment THAT DAY. 1/
I have a picture of her in my lecture to the Dev Bio students about embryonic stem cells. A pioneer in the field. Thank you for your work. RIP.
'The US National Institutes of Health (NIH) has so far not received approval to spend any of the research funding allocated in a budget bill signed into law on 3 February.'
www.nature.com/articles/d41...
INTERESTED IN SINGLE-CELL LINEAGE TRACING?
Check our new review @naturerevgenet.bsky.social from the @alejofraticelli.bsky.social lab 🎉🎉
nature.com/articles/s41...
With Victoria Parreno, we tried to update the modern manual for genetic tracing and clonal analysis.
Read link: rdcu.be/e50gy
Jeremy Berg
Shannon McKinney-Freeman
Colette Delawalla, PhD
Shannon McKinney-Freeman
Insightful seminar by Roderic Guigó: Figure 1 of the Craig Venter human genome paper (Science, 2001) was made by a Spanish PhD student who had no salary and earned his living serving tables in a Pizzeria.
In this Review, Rodriguez-Fraticelli and Parreno discuss advances in single-cell lineage-tracing methods and how their application to diverse biological processes, such as development, ageing and canc...
Roses are red, platelets are too,
Hematology keeps thriving with every breakthrough. 🩸💌
This Valentine’s Day, show some love by supporting hematology research through the ASH Foundation: ow.ly/9v8r50YcZaK
#ValentinesDay #Hematology #Donate #Fight4Hematology
Alejo Rodriguez-Fraticelli
Please can you all stop calling him Steve. This phase will probably only last a day or two. Thanks.
Lars Velten
In Otter News
American Society of Hematology
Exactly 25 years ago, @rodericguigo.bsky.social and his PhD student published the first draft of the human genome in Science. The Catalan researchers were the only two from all Spain that took part. Here they are reflecting on the huge scientific feat: www.crg.eu/en/news/25-y...
The US Congress rejected sweeping cuts to science agencies. But the NIH, the NSF and NASA have had their spending slowed.
“You’re not even a lawyer,” Pam Bondi yells at Jamie Raskin, who graduated from Harvard Law School, has written several books about the legal system, and has taught constitutional law for more than 25 years.
www.theguardian.com/us-news/2026...
Bill Grueskin
Centre de Regulació Genòmica (CRG)
Congress rejected massive cuts to US science budgets for 2026, but much of the money still isn’t flowing to researchers.
The culprit? The White House Office of Management and Budget (OMB) is quietly slow-walking the release of funds. 🧵👇
Very sad news. Gail Martin (1944-2026) was a figure in developmental biology. She pioneered the field of ES cells.
A great colleague, a friend and a lovely person.
