Genome Integrity Lab | Assistant Professor, Children's Research Institute at UT Southwestern Medical Center. We study how chromosomes segregate, break, and rearrange in cancer genomes.
www.thelylab.org
Peter Ly
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The Ly Lab is recruiting two #postdocs to study intercellular DNA transfer. Join us to tackle fundamental questions at the intersection of genome instability, cell-cell communication, and cancer evolution. Please share! 🙏
Full posting: cri.utsw.edu/careers/
Proud milestone for our lab – Congrats to our first two graduate students, Lizz Maurais, PhD, and Justin Engel, PhD (@justeng95.bsky.social)!
We also celebrated Lizz’s last day as she moves on to an exciting new adventure. Good luck Lizz!
Very excited to be sharing our new paper, just out in Nature Cell Biology!
The big question we investigate: How do migrating cells put their front 🔴 and back 🔵 in the right place?
New Online! DNA voyages through intercellular tunnels
🚨#Preprint alert! @antoranlab.bsky.social
in close collaboration with @imartincorena.bsky.social lab
www.biorxiv.org/content/10.6...
How can we study human #epithelial tissues for months in the lab, while preserving their native structures and behaviour but without passaging?
Multiple postdoc/RA vacancies to work on the Wellcome-funded team project shown below. I also have vacancies to study senescence and to develop a chemical-genetic approach to inhibit specific cyclin/CDK complexes. See thread for details. DM or email me with any questions.
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Peter Ly
How much of the human genome is essential?
Two pieces out today from our lab: 1) a method to map essential genomic intervals at gigabase scale, and 2) an argument that it's time to consider synthesizing a minimal human genome.
biorxiv.org/content/10.6...
nature.com/articles/d41...
1/n What fraction of the human genome is essential for cells?
Excited to share our preprint that explores this question by combining an unusual CRISPR system, phage promoters, and thousands of deletion launchpads.
@sudpinglay.bsky.social @jshendure.bsky.social
www.biorxiv.org/content/10.6...
Excited to finally share our preprint on mapping the genetic interaction network of the DNA damage response with combinatorial knockout screens led by Sam Hayward, Alina Vaitsiankova, and Tomas Lama-Diaz! www.biorxiv.org/cgi/content/...
Nature Reviews Molecular Cell Biology, Published online: 08 June 2026; doi:10.1038/s41580-026-00987-9This study shows that genomic DNA in the cytoplasm can transfer between mammalian cells through nanotube-like structures, integrate into the genome of recipient cells and support gene expression.
dlvr.it
Peter Ly
Ever wondered why anaphase onset looks so rapid (but maybe not perfectly synchronous). As it turns out, separase is playing a small numbers game - at least in fission yeast. Thanks to Wendi Williams, @silkehauflab.bsky.social , and everybody involved.
David Fernandez-Antoran
A decade on from the launch of an ambitious project, it’s time to revisit the reasons for constructing a human genome from scratch.
The DNA damage response (DDR) is a complex network of cellular pathways that ensures the faithful maintenance of our genomes upon a wide array of genomic insults. To elucidate the functional architect...
Chromosome segregation synchrony in S. pombe is noise-limited and arises without positive feedback. New study from Wendi Williams, Julia Kamenz @kamenzlab.bsky.social, Silke Hauf @silkehauflab.bsky.social @virginiatech.bsky.social and colleagues:
rupress.org/jcb/article/...
#CellDivision #Mitosis
Modeling human epithelia in vitro remains challenging because current systems do not fully preserve the combination of architecture, heterogeneity, clonal composition, and long-term dynamics shown in ...
