A newly identified spino-brain-spinal cord loop linking the thalamus, somatosensory cortex, and superior colliculus to descending RVMSC neurons specifically drives chronic mechanical pain, and may offer new cellular targets for intervention. #PainResearch buff.ly/FdiGUU4
In mice, a circuit between the spinal cord and various regions of the brain, centring on spinal-cord-projecting neurons in the rostral ventromedial medulla, has a key role in driving chronic pain.
