🚨 New preprint on bioRxiv!
Pericyte loss triggers hypoperfusion, BBB dysfunction, endothelial VCAM-1/type I IFN activation, venular-like transitions & delayed white matter injury linked to human SVD signatures.
Congrats Dr. Dorota Stefancova & team!
www.biorxiv.org/content/10.6...
🚨 New preprint
11,000+ human brain microvessels in cSVD.
Key findings:
• Early, bimodal pericyte loss
• Endothelial activation comes later
• Venous-like microvascular shift
• Capillary density ↑
💡 Suggests a sequential vascular pathology, not parallel.
🔗 www.biorxiv.org/content/10.6...
🚨 PhD Programme – Vascular Dementia Research
New 4-year PhD funded by BHF & UK DRI on vascular mechanisms in dementia.
Training across UCL, Oxford, Leicester & Edinburgh with lab rotations.
📅 Deadline: 14 April
🎓 Start: Sept 2026
Apply: CV + statement + 2 refs → [email protected]
Please share!
Here is the FindAPhD weblink to our BHF-DRI PhD programme!
Deadline: *April 14*
Please spread the word!!
eur02.safelinks.protection.outlook.com?url=https%3A...
The BHF-UK DRI Centre for Vascular Dementia Research welcomes Dr Mohamad El Amki(University of Zurich) for the first seminar in our vascular dementia series 🗣️
Don't miss your chance to register at the link below!
lnkd.in/ex5M-EZX
PhD at the University of Edinburgh exploring small vessel disease using imaging, AI and metabolic profiling to understand brain cell dysfunction and test therapies.
www.dementiaresearcher.nihr.ac.uk/job/phd-meta...
Development of the blood–brain barrier
👉Neural Progenitor-to-Endothelium
Wnt7a/7b-RECK-GPR124-FZD
Norrin-TSPAN12-LRP5/6-FZD4
👉Pericyte/Astrocyte-to-Endothelium
Angiotensin II
Angiopoietin 1
Shh
Circumventricular organ ❎BBB◀️WIF1
#Development 2026
journals.biologists.com/dev/article/...
Our review (with the brilliant Conor McQuaid
@axelmontagne.bsky.social
) also just came out looking at glia-vascular interactions in neurodegenerative diseases - an exciting time for the field! Check it out: pharmrev.aspetjournals.org/article/S003... #glia #neurovascular #dementia #alzheimers
🔬 PhD position at Imperial College London!
Uncover how pericytes, mysterious vascular cells, drive asthma inflammation. Use spatial transcriptomics, 3D imaging & transgenic models to unlock new therapies.
3-year funded PhD | Oct 2026 start
👉 www.findaphd.com/phds/project...
📧[email protected]
Pericyte loss precedes endothelial inflammation ⬆️VCAM1 in 👤cerebral Small Vessel Disease
11k microvessels (φ4~19 μm)🤠 in precentral gyrus grey & white matter
N=20👤
Morph-O-Matic 2D cell segmentation
zenodo.org/records/1735...
@axelmontagne.bsky.social bioRxiv 2026
www.biorxiv.org/content/10.6...
Axel Montagne
Axel Montagne
Axel Montagne
Axel Montagne
www.biorxiv.org
www.biorxiv.org
PhD at the University of Edinburgh on small vessel disease using imaging, AI & metabolic profiling to study brain cell dysfunction and test therapeutic targets.
Dysfunction of glial and vascular cells is increasingly recognized as a central feature
of neurodegenerative diseases. Growing evidence points to disruptions in glial-vascular
interactions, which are ...
