Postdoctoral Researcher at the Collepardo Lab, in Cambridge, working on chromatin phase separation
She/Her :) A science, dog, photography person, and most of all, an absolute chromatin geek
Julia Maristany
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1/New preprint just dropped! 🔥🔥 We investigate how the genome is destroyed in apoptotic cells in a way that prevents DNA fragments from spreading beyond the dying cell 🧬⚰
Done here at @imbavienna.bsky.social & in the super @rcollepardo.bsky.social & Rosen labs:
www.biorxiv.org/content/10.6...
Our central finding is that nucleosome stability emerges from an interplay between:
🧬 DNA elasticity
⚛️ Histone chemistry
📐 Nucleosome geometry
And that genomic sequences operate in a narrow “Goldilocks zone” of DNA flexibility that balances thermodynamic stability with mechanical plasticity
In this work, we explore a deceivingly simple question:
How does DNA sequence and histone chemistry tune the mechanical plasticity of nucleosomes?
What we find is that DNA sequence encodes a mechanical “dial” that shifts nucleosomes between stable and plastic regimes 🧬
Please visit the preprint! We are very proud of this work - but also, this paper means a lot to me:
Jan and I met and started dating while working on it. Later, we worked on many more projects together, but this was the first. Some projects shape your science - this one shaped my life, too ❤️
