Systems Microbiology @EMBL, combining high-throughput approaches & mechanism in bacteria, antibiotics, microbiome, infection, species diversity, cell envelope
https://www.embl.org/groups/typas/
Typas Lab
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Great collaboration inside and outside @embl.org @EMBLHeidelberg with @savitski-lab.bsky.social @zimmermannlab.bsky.social @sarsarela.bsky.social y.social @linairmi.bsky.social Gad Frankel @imperialcollegeldn.bsky.social and others
#Microbiome #AntibioticResistance #AMR
Very excited to share our new paper out in Nature. Congrats to Xiaoqian (Annie) Yu and all the coauthors. www.nature.com/articles/s41...
Overall, we demonstrate that specific microbiota compositions affect the fitness of resistant strains through carbohydrate competition, offering a path towards microbiota‑based interventions that actively counter‑select antibiotic-resistant strains without disrupting susceptible community members.
Mechanistically, glyR mutations upregulate the glycoporin GlyP, improving growth in glycerol-rich niches but carrying costs elsewhere. These mutations are under conditional positive selection in clinical isolates, showing how microbiota context can shape the evolution of resistance.
Check our new preprint by Knopp M. et al.!
Human gut microbiomes can impose strong +/- selection for resistant versions of resident opportunistic pathogens. In the case we follow up, selection is driven by altered carbohydrate utilisation that the resistant mutant evolves. doi.org/10.64898/202...
Out Now! In silico typing maps the natural diversity of Escherichia coli transporter-dependent capsules #MicroSky
We found that E. coli can be a key driver of selection for a high-fitness antibiotic resistant K. pneumoniae strain in complex communities. Higher-order interactions with other community members could enhance or decrease the selective advantage of the resistant mutant.
We introduce a high-throughput method to quantify resistance-associated fitness costs inside complex gut microbiomes. This lets us identify which microbiota are permissive or restrictive for antibiotic-resistant pathogens.
Out Now! Cayman enables large-scale analysis of gut microbiome carbohydrate-active enzyme repertoires #MicroSky
