Assistant Professor of Pathobiology at the University of Pennsylvania. We use trees to study RNA virus evolution and transmission, with a focus on avian influenza. viruses, sequencing, phylogenetics, pop gen. She/her
https://lmoncla.github.io/monclalab/
Louise H. Moncla
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Together, this study suggests that reassortment is frequent, seasonal, and mostly driven by viral prevalence and mixing with LPAIs. This suggests that aspects of reassortment (timing, host, locations) may be more predictable if we understood transmission better. Our data also suggest that HPAI
Please share! My lab has an open fully-funded PhD position at Vilnius University's Life Sciences Center in Lithuania. The PhD project will involve identifying missing orthomyxovirus segments from public sequence data. Applicants must hold an MSc by June & have bioinformatics experience. 1/2
Louise H. Moncla
Using these time-varying rates, we show that the probability of reassortment in the 6 months leading up to the emergence of B3.13 and D1.1 was ~0.15, meaning that viruses evolving during particular times of year are likely to be reassortants, regardless of whether reassortment was beneficial.
flyway, and time of genotype origins as a proxy for reassortment. We find that genotypes mostly arise in flyways and hosts proportional to what you would expect based on the transmission they support, with the Central flyway and geese generating more reassortment than you would expect, and cattle
We find that that reassortment is frequent, seasonal and mostly driven by mixing between high and low path viruses. Peaks in HPAI reassortment are best predicted by LPAI cases, indicating that LPAI ecology plays a major role in the timing of HPAI reassortment.
Next, Nicola developed a new version of CoalRE that allows reassortment to be modelled as a function of prevalence. We inferred the full reassortment network and measured reassortment rates over time, and used a GLM to assess whether cases of HPAI or LPAI correlated with reassortment.
In collaboration with Nicola Muller, and led by @lambod50.bsky.social, we have a new preprint out that's all about reassortment! www.biorxiv.org/content/10.6...
Using TargetedBeast, we built massive (9000 tips!) Bayesian phylogenies of North American H5Nx viruses, and inferred the host...
Gytis Dudas
evolution is pretty fundamentally linked to the ecology and spread of LPAI viruses, which we should probably surveil and understand better.
Huge thank you to all the people at USDA who generated these sequence data, to @lambod50.bsky.social and Nicola for all their fantastic work on this!
Excited to announce that we are moving the lab to Minneapolis to join the University of Minnesota Department of Microbiology & Immunology and Institute on Infectious Diseases this summer!!
We will be hiring so please reach out if interested in viral evolution, viral immunology, etc.!!
Louise H. Moncla
Louise H. Moncla
Louise H. Moncla
www.biorxiv.org
Louise H. Moncla
Louise H. Moncla
Louise H. Moncla
generating less. Ducks contributed the most to transmission, and contributed about half of all reassortant segments! So ducks are really the source of new H5 genotypes in North America, making them a useful target for surveillance.
