Working at the interface of DNA replication, transcription, chromatin and nuclear organization. Passionate about genome functionality. María Gómez Lab
Genome Function Lab
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Congrats to the whole team!
Although cohesin-sensitive, long-range enhancer activation is equivalent in nature to proximal activation. Cooperativity can arise from different levels of activation inputs operating on a non-linear response function. @eliasfriman.bsky.social @uoe-igc.bsky.social
www.biorxiv.org/content/10.6...
Our preprint describing the moonlighting functions of SEC13 in NMD and regulation of the UPR is out now in bioRxiv www.biorxiv.org/cgi/content/...
Superinspiring!-as always
Superb science and great atmosphere! It is a pleasure to attend the R2G2 meetings!
Members of the Lab, with other PhD students and postdocs from @cbm-csic-uam.bsky.social, had an inspiring conversation with Dr. Juan Méndez (cniostopcancer.bsky.social) on what PIs expect from new postdocs and academic career opportunities. A truly enriching exchange! ✨
Our postdoctoral researcher @joanasgrmrtnz.bsky.social, together with other researchers from @cbm-csic-uam.bsky.social, has participated in the video by @contracancerinv.bsky.social to commemorate **Women’s Day (#8M)** to recognize the strength, dedication and talent of women in science 💜
Our new paper is finally out! 📢
Great team effort from Sara M, @joanasgrmrtnz.bsky.social and @agalleg.bsky.social with the support from everyone in the lab.
Many thanks to our collaborators, @andreichabes.bsky.social , @mmaslon.bsky.social and @lschermelleh.bsky.social
Happy to share our first preprint! Led by @joseruiziglesias.bsky.social — EpiFlow: multidimensional single-cell epigenetic profiling by spectral flow cytometry
Many thanks to @cbm-csic-uam.bsky.social, @ageinves.bsky.social and Fundación Ramón Areces for their support
www.biorxiv.org/content/10.6...
We go live!!!
Join us Munich July5-7th to hear exciting research on #Replication by leaders in the field
AND !! registration is FREE 🥳 (but mandatory) - we hope to see many in Munich 🍺 @helmholtzmunich.bsky.social
@replifate.bsky.social @epicrossborders.bsky.social
replifate.eu/event/meetin...
Slowing RNAPII velocity boosts naive pluripotency, uncovering an unexpected link to cell plasticity.
Neuroepigenetics of brain physiology and pathology Lab
ME Torres-Padilla
Video
06-07 July 2026 | Munich, GermanyDNA Replication and Its Impact on Genome and Chromatin MaintenanceWe are RepliFate, a European Training Doctoral Network dedicated to understanding how DNA replication...
The epigenetic landscape of individual cells determines their identity and function, yet current methods for profiling chromatin modifications at single-cell resolution remain low-throughput, costly, or limited in parametric depth. Here we present EpiFlow, a spectral flow cytometry-based platform that enables the simultaneous quantification of 16 epigenetic markers, including histone post-translational modifications, DNA methylation, and hydroxymethylation, at the single-cell level. We demonstrate that EpiFlow is robust across species from yeast to mammals and resolves biologically meaningful epigenetic transitions during the cell cycle, stem cell differentiation, germinal centre B cell maturation, diabetic liver remodelling, and seizure-induced chromatin reprogramming. High-dimensional integration of EpiFlow data enables cell-type classification based solely on epigenetic profiles in liver, brain, blood, and cancer. Furthermore, EpiFlow detects on-target and off-target/indirect effects of epigenetic drugs in a high-throughput-compatible format. Collectively, these results establish EpiFlow as a broadly applicable platform for single-cell epigenetic analysis in basic, pharmaceutical, and translational research. ### Competing Interest Statement The authors have declared no competing interest. Agencia Estatal de Investigación, PID2022-137384OA-I00 (ERDF /EU), RYC2021-031713-I (European Union NextGenerationEU/PRTR), EUR2024-153539, CNS2024-154632 Fundación Ramón Areces, CIVP22A7609
“I think it’s a real mistake to forget where the pipeline for all this begins.”
John Diffley reflects on the importance of basic research, his mission to decode DNA replication and recreate it in the lab, and the scientific optimism of the 1960s that helped shape it.
www.crick.ac.uk/news/2026-03...
Video
Some of these mechanisms are also recapitulated by human p53 versions when expressed in Drosophila cells, suggesting broader relevance beyond the fly system. 9/9
Read the paper here: www.nature.com/articles/s41...
The 2nd Genomic Regulatory Network Annual Meeting, organised by the CBM & funded by @AgEInves, is a great success. Over 3 days, researchers are sharing exciting results, building collaborations, and strengthening connections across institutions.
@csic.es @uam.es
The Francis Crick Institute
Cell Death & Disease - Transcription-dependent and -independent functions of Drosophila p53 isoforms in the induction of apoptosis and senescence-associated tumorigenesis
