I'm very happy to share this review, written with Dan Blears, on a new interpretation of promoter-proximal pausing in the context of a transcription checkpoint. We're not the only ones with these ideas, but they've not been sufficiently explored the way we do here: genesdev.cshlp.org/content/earl...
Danes offer to buy California to spite Trump’s Greenland aims: ‘We’ll bring hygge to Hollywood’
Jesper Svejstrup
The Guardian
One day the US will have to face the shame and horror of what has happened here: that a cabal of wealthy people have elevated a monster into the most powerful person in the world www.nytimes.com/2025/11/12/u...
Setting up shop in advance of closing our profile on X.
Excited to share our latest paper, now online in Molecular Cell. First, it shows that the RNAPII-CTD kinases CDK9 and CDK12 are Ser5-Ser2 kinases. Secondly, it describes the activation mechanism of CDK12/13 by PAF1C complex. Congratulations to David López Martínez and coauthors!
lnkd.in/d_nbfMht
Jesper Svejstrup
Looking for 2 or more highly motivated PhD students to join our quest to understand the interplay between gene expression, genome instability, and human disease
jobportal.ku.dk/phd/?show=16...
Deadline: March 6, 2025
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Jesper Svejstrup
I’m very happy to share Zhong Han’s beautiful work on the biochemical function of Senataxin, encoded by a gene that is mutated in rare and early-disabling neurodegenerative diseases. Turns out it rescues backtracked RNA polymerase II during early transcription! www.sciencedirect.com/science/arti...
Extremely proud to share the impressive work done by Anouk Olthof et al. on how cells maintain healthy levels of RNAPII, and how they respond when levels are too low. Fascinating stuff, we think www.biorxiv.org/content/10.1...
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Satirical petition from Denmark, which owns Greenland, racks up 200,000 signatures as Trump eyes Arctic island
Since returning to the presidency last month, Donald Trump has called for Canada to become the 51st US state, suggested he might take over the…
Transcription is regulated by sequence-specific transcription factors and enzymes allowing access to genes in chromatin. However, recent data indicate that the abundance of RNA polymerase II (RNAPII) ...
Senataxin (SETX) regulates RNA polymerase II (RNAPII) transcription and helps maintain genome stability, at least partly by suppressing R-loops. Howev…
