Online now! Online now! Chemical modulation of Miro1 alleviates cell-type-specific vulnerabilities in Friedreich’s ataxia #chembiol
Chandra et al. leverage a human dual-cell model of FA and discover cell-type-specific vulnerabilities to frataxin deficiency. A Miro1-binding probe, MR3, modulates FA cell-type-unique molecular signatures and alleviates mitochondrial damage via potential allosteric reshaping of Miro1 protein. Previously unreported Miro1 ligands expand MR3 chemical diversity.
