Online now! Online now! Optogenetic control of plasma membrane O-GlcNAcylation regulates WNK1 condensates and cellular signaling #chembiol
Zhu et al. develop a red-light optogenetic tool to enable spatiotemporal control of O-GlcNAcylation at the plasma membrane. They demonstrate that light-induced O-GlcNAcylation inhibits WNK1 biomolecular condensate formation, thereby suppressing the osmosensing pathway. This work provides a versatile platform to precisely manipulate glycosylation and regulate cell signaling.
