Online now! Online now! Chemical biology tools for studying histone post-translational modifications #chembiol
Histone post-translational modifications regulate gene expression, yet linking specific marks to their regulatory enzymes remains challenging. Douglas and Seath review chemical biology strategies—spanning synthetic peptides, semisynthetic nucleosomes, and intact chromatin—that systematically map PTM-dependent interactions, highlighting how increasing biological complexity advances functional understanding of the histone code.
