Structural insights into inhibition mechanism of the helicase-primase complex from human herpesvirus 1
Sato et al. determine high resolution structures of the human herpesvirus 1 helicase primase complex (HPC), revealing how clinical inhibitors allosterically inactivate the HPC. Their findings illuminate α-subfamily drug specificity and offer a structural basis for developing antivirals targeting a wider range of herpesviruses.
