Nature Reviews Gastroenterology & Hepatology, Published online: 19 May 2026; doi:10.1038/s41575-026-01215-7Dietary assessment commonly relies on asking people what they remember eating. Genomic methods can change this assessment, paralleling how DNA sequencing revolutionized microbiology. By identifying consumed foods directly from stool, these approaches offer an objective, scalable alternative that gastroenterology researchers can begin using today.