The conference “Mitotic spindle: From living and synthetic systems to theory” is open! www.phy.pmf.unizg.hr/~mitosis/
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Using a point mutant that disrupts autoregulation (γ-tubulin R3H), we revealed deregulated protein levels and microtubule-nucleating activity. These changes led to a loss of mitotic fidelity, highlighting the importance of precise γ-tubulin dosage.
You are finishing your PhD and looking to continue in science?
The Martin lab @biology-unige.bsky.social has an open postdoctoral position in cell biology to study cell-cell fusion. For more information, please consult mocel.unige.ch/research-gro....
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Sad to miss this year’s ASCB meeting! But the lab is represented - don’t t miss @ac-almeida.bsky.social and her poster P0101. She will take you into the world of tubulin quantity control, microtubule dynamics, cell and tissue architecture.
New preprint from the lab 🎉: γ-tubulin is a novel target of the tubulin autoregulation pathway! Previously thought to exclusively target α- and β-tubulin mRNAs, we show that the TTC5–SCAPER–CNOT11 axis also degrades γ-tubulin mRNA, expanding the scope of this fundamental regulatory mechanism.
Lab’s 2nd story aired today!
Fantastic @ac-almeida.bsky.social cracks the cellular function of tubulin autoregulation - an over four decades old enigma!
Read on to learn how she deployed human 3D cell culture models to link tubulin homeostasis to tissue organization & viability. Bravo Ana! 👏🏻🍾
The Mitotic Spindle Meeting in Dubrovnik, organized by Iva Tolić @ivatolic.bsky.social and Nenad Pavin, has been a real festival of mitosis! Fantastic science and community. While the spectacle goes on for another day, I’m leaving inspired and energized. #SpindleSroatia2026
Arresting mitosis with visible light! Brilliant Victoria von Glasenapp from the Gotta and Winssinger labs @UNIGE develops a cool photo-caged PLK1 inhibitor, which we deploy in 3D spheroids to control mitosis with exquisite spatio-temporal precision. Check out the original article: lnkd.in/eTnzy5Nc
www.biorxiv.org/content/10.6...
TTC5 binds the γ-tubulin N-terminus (MPREI), revealing unexpected flexibility in the autoregulatory motif. Mutating MPREI completely abolished mRNA regulation, and further allowed us to probe the functional implications.
Sophie G Martin
Ivana Gasic
Ivana Gasic
Ivana Gasic
Ivana Gasic
Ivana Gasic
Ivana Gasic
Ivana Gasic
Light is a powerful tool for controlling biological processes. Here, the authors demonstrate its use to modulate inhibitor activity and diffusion, enabling precise control of cell division in multicel...
Microtubule organization relies on the precise control of tubulin abundance to ensure accurate cytoskeletal function and faithful cell division. While α- and β-tubulin levels are controlled by a well-...
🔎New preprint!
We reveal a physiological role for tubulin autoregulation, fine-tuning microtubule dynamics and preserving 3D cellular architecture.
Big thanks to @ivanagasic.bsky.social and team!
Link below for all #cytoskeleton & #spheroid enthusiasts👇(1/5)
www.biorxiv.org/content/10.1...
Heading to #CellBio2025 @ascbiology.bsky.social @embo.org?
Stop by my poster P0101 tomorrow (Sun, 12:45 PM) in the session “Cytoskeleton and Motility-Microtubule Organization and Dynamics”.
Looking forward to lively discussions on tubulin regulation & microtubule organization. See you in Philly!
