Finished a human genome, working on a few more 👨💻
Lab: https://genomeinformatics.github.io
Posts are my own
Adam Phillippy
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Now published: journals.plos.org/plosbiology/...
Revamped the teaching materials site. Light/dark mode switch at the top. More consistent, compact presentation of all the materials. + Icons and such! www.langmead-lab.org/teaching.html
Mutation rates per generation are strikingly similar across germlines of animals and across at least one somatic cell type, suggesting a key role for natural selection in shaping mutation rates. This ...
T2T assemblies for nearly all major Y chromosome haplogroups courtesy of a collab between @humanpangenome.bsky.social and HGSVC! What was once the hardest human chromosome to finish can now be routinely assembled thanks to ONT + Verkko www.biorxiv.org/content/10.6...
Happy to highlight an essay I wrote together with @marcdemanuel.bsky.social,
@natanaels.bsky.social and Anastasia Stolyarova, trying to think through what sets the mutation rate of a cell type in an animal species: www.biorxiv.org/content/10.6... 1/n
We are excited to share our pan-pangenome paper! This is a long time coming work of my postdoc with the incredible @psudmant.bsky.social, and a stellar group of people! I hope you enjoy reading it! And I am excited to talk more more about it this week at #PEQG26!!
www.biorxiv.org/content/10.6...
A big preprint from my group!
Muller Elements are considered to be conserved in flies. We tested it by reconstructing the ancestral dipteran karyotype using 340 chromosomal genomes and suprise suprise, they're not...
Led by @juliagries.bsky.social and Sam Ebdon. www.biorxiv.org/content/10.6...
🧵👇
Adam Phillippy
Germline mutation rates per generation are strikingly similar across animals, despite vast differences in life histories. Analogously, in at least one somatic cell type, mutation rates at the end of l...
www.biorxiv.org
Complete, haplotype-resolved genome assemblies have provided unprecedented insight into the evolution of structurally complex, rapidly evolving regions of human genomes; however, population-scale pang...
🧬New from @ahoischen.bsky.social & co!
📄HiFi sequencing accurately identifies clinically relevant variants in paralogous genes
🦋🌿High-quality genomes begin with quality biological material.
🐝 Before sequencing, each species is identified, documented, collected, and preserved to ensure integrity. For insects, this requires field expertise, taxonomy, and preservation workflows.
Biodiversity genomics starts with the specimen🐞
Long-read HiFi genome sequencing combined with Paraphase enables comprehensive detection
of all clinically relevant variant types in paralogous genes. It resolves “dark” regions
while enabling haploty...
Old friend and new @jhucompsci.bsky.social colleague @benlangmead.bsky.social visited the NIH today and presented a great talk on pangenomes and BWT at exactly the level I need to hear it 🚣 🚣 🚣 😆 Thank you Ben!
Adam Phillippy
Off to the first of five “Summer of Nanopore” workshops. More than 100 faculty across the U.S. be trained, joining a growing network of educators making genome sequencing a routine part of classroom learning and research experiences. Box 1 of 3; water surveillance mobile lab!
