Clinical Professor of Muscle Physiology and Regeneration after Traumatic Soft-tissue Injury @ismcopenhagen.bsky.social
https://orcid.org/0000-0002-2017-4580
#MyoBlue
Abigail Mackey
We are hiring a POSTDOC on an NIH award to measure inertial effects of (in)active muscle. Please share and re-post widely! Please send expressions of interest to my UML email.
💪new 1st author publication @grithhojfeldt.bsky.social and Joris Michaud from fantastic #CollaborativeScience team effort bewteen @ismcopenhagen.bsky.social and Nestle @feigelab.bsky.social on the role of NAM/PN in human muscle regeneration🙌🏃🙌
advanced.onlinelibrary.wiley.com/doi/10.1002/...
We’re now on LinkedIn! Check us out and follow us there!
www.linkedin.com/feed/update/...
just got knocked over by this new paper from the Andrei Chagin lab: www.science.org/doi/epdf/10....
physically dropped the paper in delighted surprise when I got to the second half of Fig 5:
Great team involved in this review based on a conference we organized at the University of Jyväskylä, Finland. @uniofjyvaskyla.bsky.social
tinyurl.com/27zupuhc
@abigailmackey1.bsky.social @mackinprof.bsky.social
@wimderave.bsky.social and others not yet in Bluesky.
🚨 We are hiring TWO postdocs to join the Cell Migration Lab (cellmig.org) 🇫🇮 as part of the new Centre of Excellence in Immune–Endothelial Interfaces (IMMENs).
Join us to decode immune regulation & develop next-gen imaging tools! 🧪🔬
Details in thread 🧵👇
#ScienceSky #Postdoc #AcademicJobs Please RT🫶
"Prespecified analysis plans are not suitable for exploratory experimental physiology research"
physoc.onlinelibrary.wiley.com/doi/10.1113/...
@abigailmackey1.bsky.social
We wrote about the potential reasons why some people respond less to training and about new highlights in resistance training research presented in November 2026. But we also criticize the concept of individual variation in exercise adaptations and suggest new study designs.
3 factors can explain most of the variation in individual responses to HReT: measurement error, within-person biological variability, and true effect of the intervention
🙌Casper Soendenbroe for generating these data from another
@ismcopenhagen.bsky.social study!
journals.plos.org/plosone/arti...
We wrote this letter to address the overly rigid preregistration requirements imposed now by many journals on exploratory experimental physiology research - time to align guidelines with contemporary research methods!
@ismcopenhagen.bsky.social
@proferichter.bsky.social
doi.org/10.1113/EP09...
In a randomized clinical trial, we test the potential of combined nicotinamide (NAM) and pyridoxine (PN) to improve muscle recovery through muscle stem cell (MuSC) activity. Daily oral NAM and PN sup....
New year, new location for our Thursday morning Department meetings in the Fælleshuset! And posting this on our new LinkedIn page!
We were delighted to be joined by Kristian Villars Lolck from the Ge...
The Inter-Individual Variation in Resistance Training Response Conference was hosted at the University of Jyväskylä, Finland November 19-21, 2025. This paper summarizes key themes that emerged across lectures and discussions. First, resistance training induces multi-dimensional adaptations at the tissue, muscle fiber, and ultrastructural levels, including radial muscle fiber hypertrophy through increased myofibril number, longitudinal growth through sarcomere addition throughout the length (not ends) of muscle fibers, and metabolic adaptations that emulate other models of rapid cell growth. Second, training program variables including weekly sets, volume-load, rest interval duration, and training proximity to failure meaningfully influence hypertrophic outcomes in the general population, whereas exercise selection can be flexible. Third, age as well as molecular signatures prior to and in response to training influence inter-individual response heterogeneity. Finally, while inter-individual variability in observed hypertrophic responses is considerable, delineating true inter-individual variability from random variation remains challenging. Hence, study design considerations that can be thoughtfully applied to enhance rigor include repeat validation trials, unilateral within-subject designs, minimum clinically important difference thresholds, and multivariate composite responder classifications. This paper aims to summarize conference highlights while also providing meaningful implications for both researchers and practitioners and advancing current thinking on heterogeneity in the resistance training response.
Background The extent of inter-individual variability in response to heavy resistance exercise training (HReT), and the possible existence of non-responders, remains unclear. This study aimed to deter...
