Senior Scientist at Penn Lifespan Informatics and Neuroimaging Center (PennLINC) studying psychedelics and the brain.
sypres.io
Parker Singleton
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Here's bonus slides on cross-validation tests, separate from our preprint. Covering:
1. paired (sign-flip) permutation test
2. label-swap permutation test
3. sample-level vs fold-averaged stats
4. a common misapplication of the corrected t-test
5. three bootstrap variants 1/N
And here's our second installment of sypres.io, co-led by the brilliant @bsevchik.bsky.social !!
I always assumed that brain function had to line up with cytoarchitectonics.
It turns out I was wrong.
Human cortex, especially PFC, is tiled by chains of functional patches that subdivide and interlink architectonic areas into parallel processing streams.
www.biorxiv.org/content/10.6...
Nice article on our recent Nature Mental Health paper: www.medscape.com/viewarticle/...
Diffusion MRI (dMRI) is a powerful tool to study white matter maturation. In our new preprint, we process and distribute a new resource of >24,000 ABCD dMRI scans using open source tools! We then evaluate how methods shape inferences about development.
🔗 www.biorxiv.org/content/10.6...
Excited that this is officially out there in the world. Check out the dashboard and visualizations! Huge shout out to Parker and Brooke, who led this herculean effort. More to come!
Thrilled to share our latest paper, out recently in Nature Mental Health.
"Optimizing functional connectivity scanning conditions for predicting autistic traits"
www.nature.com/articles/s44...
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Thomas Yeo
Sypres.io continuously tracks and evaluates psychedelic research, offering an up-to date view of study findings, design, and limitations.
In a meta-analysis of 210 biomedical AI studies that statistically compared models under cross-validation, 97% used invalid statistical tests.
Here's our new preprint doi.org/10.64898/202... led by @tianchu.bsky.social @hetuli.bsky.social @shaoshiz.bsky.social @nichols.bsky.social 1/N
Parker Singleton
Incredible work by the absolutely stellar @bsevchik.bsky.social and @parkersingleton.bsky.social — the second installment of our open-science living meta-analysis of psychedelics for mental health.
Beyond delighted to see this paper -- our first from the SYPRES initiative -- now out at @natmentalhealth.nature.com. Check out Parker's awesome thread below, w/ links to dashboard + all code + data.
Evan Gordon
This paper has been a long time coming. Instead of reanalyzing the same old resting-state fMRI datasets, we combined nearly all datasets around the world. Note that we didn't exactly find indisputable evidence for "default mode network disintegration."
www.nature.com/articles/s41...
Analysis of neuroimaging datasets across five major psychedelics revealed a shared brain signature and provides a comprehensive insight into how these drugs reorganize brain architecture.
🍄 Our new living systematic review and meta-analysis on MDMA for PTSD is now live on medRxiv. Here's what we found and how we built upon our open science infrastructure to support it 🧵
www.medrxiv.org/content/10.6...
🍄 Our new living systematic review and meta-analysis on psilocybin for depression is out now in Nature Mental Health. Here's what we found and the open science infrastructure we built to support it 🧵
Open-Access Link: rdcu.be/fbU5V
This research investigates optimal brain states for predicting autistic traits using connectome-based predictive modeling across four datasets. Findings indicate that a sustained attention task enhanc...
🍄 Our new living systematic review and meta-analysis on psilocybin for depression is out now in Nature Mental Health. Here's what we found and the open science infrastructure we built to support it 🧵
Open-Access Link: rdcu.be/fbU5V
Nature Mental Health - This study presents a living systematic review and open-data meta-analytic database from 15 randomized controlled trials examining the effects of psilocybin treatment on...
rdcu.be
Nature Mental Health - This study presents a living systematic review and open-data meta-analytic database from 15 randomized controlled trials examining the effects of psilocybin treatment on...
🍄 Our new living systematic review and meta-analysis on MDMA for PTSD is now live on medRxiv. Here's what we found and how we built upon our open science infrastructure to support it 🧵
www.medrxiv.org/content/10.6...
Take a look at some of our latest results, diving into task-fMRI data, autism, and predictive modelling:
"What is the best brain state to predict autistic traits?"
www.medrxiv.org/content/10.1...
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Parker Singleton
Parker Singleton
Brooke Sevchik
Corey Horien
Brooke Sevchik
3,4-methylenedioxymethamphetamine (MDMA) has emerged as a potential treatment for post-traumatic stress disorder (PTSD), generating considerable enthusiasm in the field. However, rapidly changing evid...
3,4-methylenedioxymethamphetamine (MDMA) has emerged as a potential treatment for post-traumatic stress disorder (PTSD), generating considerable enthusiasm in the field. However, rapidly changing evid...
Autism is a heterogeneous condition, and functional magnetic resonance imaging-based studies have advanced understanding of neurobiological correlates of autistic features. Nevertheless, little work h...
