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Rapid publication of organic synthesis, physical organic, chemical biology and supramolecular chemistry research. Published by @rsc.org 🌐 Website: rsc.li/orgbiomolchem
Organic & Biomolecular Chemistry









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Don't miss this review in our latest issue by Thierry Besson, Corinne Fruit et al. @univrouen.bsky.social highlighting the recent renewal of interest in the synthesis of 2-cyanobenzothiazole for biomedical research #orgchem Check it out in full on our website🔽
We have partnered with the #SBNP conference taking place in Playa del Carmen, Mexico from 01 – 04 November 2026. This is not a conference to miss out on! Click here to register now: bit.ly/3QQrw6o
Don't miss this paper in our latest issue by Bishwajit Ganguly, Irishi N. N. Namboothiri et al. from IIT Bombay showcasing the utility of α-halodicyclopentadienones for the synthesis of novel fused heterocycles #orgchem Check it out in full here
Take a look in our latest issue at this paper by Yu-Tong Huang & Che-Chien Chang describing intramolecular difunctionalization of alkynes involving cascade radical 1,4-heteroaryl migrations #orgchem 📍Fu Jen Catholic University
Be sure to read this paper by Chinna Ayya Swamy P & co. from NIT Calicut in our latest issue investigating how π-spacer units effect 2,6-disubstituted BODIPY fluorophores mitochondrial imaging #orgchem Find their full report on our website👇
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🔓Check out this #OpenAccess review from Jungwon Kim et al. at Gyeongsang National University looking at the recent advances in allylic and vinylic C–H bond functionalization of simple alkenes via visible-light photocatalysis #orgchem Read it in full below👇
🔓Read #OpenAccess research from Raymond Schinazi, Franck Amblard & co. @emorydeptofmed.bsky.social in our latest issue reporting the stereoselective synthesis of 1′-α-cyano carbocyclic pyrimidine nucleoside analogs #orgchem #medchem Find the full paper on our website🔽
📢Our latest issue is now online! Check out the paper behind the cover by Jian Yin & co. at Jiangnan University describing how photocaging the C6-carboxylate of β-glucuronide prodrugs enables spatiotemporally controlled release of anticancer agents #orgchem #medchem pubs.rsc.org/en/content/a...
📢Our latest issue is now online! 🔓Check out the #OpenAccess paper behind the cover by Mitsuhiro Arisawa & co. at University of Osaka reporting a rhodium-catalyzed reaction combining long-range alkyl chain-walking with selective cyclopropyl C–C bond cleavage #orgchem pubs.rsc.org/en/content/a...
Don't miss research in our latest issue reporting a one-step synthesis of Zolpidem and its analogues via visible light induced coupling of imidazo[1,2-α]pyridines with 2-bromoacetamides by Wei Deng, Ze Tan et al. from Hunan University #orgchem Check it out here🔽
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Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry
Benzothiazole structures are widely present in many drugs and natural product molecules. A renewal of interest in 2-cyanobenzothiazole derivatives is mainly prompted by their noteworthy utility for…
pubs.rsc.org
2-Cyanobenzothiazole: a journey from darkness to stardom
Mitochondria are highly dynamic subcellular organelles that serve as central hubs of energy metabolism, signaling, and stress regulation, and their dysfunction is closely linked with a wide range of…
pubs.rsc.org
π-Spacer effects in 2,6-disubstituted BODIPY fluorophores for mitochondrial imaging
Several versions of the intramolecular difunctionalization of alkynes involving a variety of 1,4-heteroaryl migrations were explored to produce a series of β-heteroaryl-γ-lactams. Five…
pubs.rsc.org
Intramolecular difunctionalization of alkynes involving cascade radical 1,4-heteroaryl migrations and formal total synthesis of a β-imidazolyl-γ-lactam alkaloid: isoanantine
A base-mediated Michael addition of amidines, oxindoles and thio-oxindoles to α-halodicyclopentadienones (halo-DCPD-enones) followed by cyclization of the intermediate Michael adducts leads to linear…
pubs.rsc.org
Utility of α-halodicyclopentadienones for the synthesis of novel fused heterocycles
pubs.rsc.org
The selective functionalization of allylic and vinylic C–H bonds in simple alkenes represents a powerful yet challenging strategy for the direct construction of value-added molecular architectures…
Recent advances in allylic and vinylic C–H bond functionalization of simple alkenes via visible-light photocatalysis
1′-α-Cyano nucleoside analogs have emerged as key structural motifs as antiviral agents. Due to their importance, we developed a novel stereoselective synthetic route to access 1′-α-cyano carbocyclic…
Stereoselective synthesis of 1′-α-cyano carbocyclic pyrimidine nucleoside analogs via a chelation-controlled 1′-α-hydroxymethylation strategy
pubs.rsc.org
A novel and efficient strategy for synthesizing the drug Zolpidem and its analogues via the coupling of imidazo[1,2-α]pyridines with 2-bromoacetamides under blue LED irradiation has been developed.…
pubs.rsc.org
One-step synthesis of Zolpidem and its analogues via visible light induced coupling of imidazo[1,2-α]pyridines with 2-bromoacetamides