Senior Scientific Editor at Immunity, Cell Press @cp-immunity.bsky.social; fan of science (especially immunology), space, & nature; views are my own
https://www.cell.com/immunity/home
Kavitha Scranton
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Resistance of IgG–FcR interactions to shear stress can be engineered, establishing a separate parameter for optimizing antibody effector functions beyond affinity alone.
www.cell.com/immunity/pdf...
Congratulations to Dr. Bowie Cheng and the whole team 🎉.
My new comprehensive review of Immune Memory to Vaccines is out! It has an emphasis on human vaccines. It is also accompanied by a full video lecture. Enjoy!
@lji.org @cp-immunity.bsky.social
authors.elsevier.com/sd/article/S...
New paper reveals how the human immune system fights #malaria caused by Plasmodium vivax, opening new avenues to develop #vaccines against the most widespread form of malaria. Published in @cp-immunity.bsky.social
@burnetinstitute.bsky.social @wehi-research.bsky.social
doi.org/10.1016/j.im...
State-specific enhancer landscapes govern microglial plasticity @cp-immunity.bsky.social www.cell.com/immunity/ful...
Excited to share my paper published today in @cp-immunity.bsky.social! We find that when CTLs integrate antigen and cytokine signaling, the timing of these cues matters - shedding light on an old question: Why do NK cells sometimes behave like CD8+ T cells?
www.sciencedirect.com/science/arti...
Those who know me, know I’m not someone who changes his preferences & behaviors lightly. As Ron Swanson said, “I regret nothing. The end.” Well, let me tell you about our new study, out from The Perry Lab @mskcancercenter.bsky.social in @cp-immunity.bsky.social, which is the exception. /1
Excited to share our new paper in @cp-immunity.bsky.social showing that "Germline-targeting HIV immunogen induces cross-neutralizing antibodies in outbred macaques" A promisingstep toward an HIV vaccine advancing soon to human clinical testing! Immunity www.cell.com/immunity/ful...
Check out this cool new paper from Mike Rogers lab @garvaninstitute.bsky.social out in @cp-immunity.bsky.social! Their new model of MKD deficiency (aka Hyper IgD syndrome) as a "prenylopathy": NK cell degranulation defect -> compensatory increase IFN gamma -> autoinflammation. Can Rx with JAKi!
Two new KI studies published in @cp-immunity.bsky.social have mapped immune gene variation across multiple global populations and shown how these variations affect the ability to form neutralising antibodies, for example against the #influenza virus 🧪 #Immunology #Genetics news.ki.se/large-mappin...
Prof. Shane Crotty
Taia Wang Laboratory
James Beeson
John Lukens
John Lukens
The mechanisms linking defective protein prenylation to systemic inflammation in mevalonate
kinase deficiency remain unclear. Munoz et al. reveal that mice and humans with MKD
have defective NK cells,...
Lymphocyte differentiation during infection depends on the integration of antigen and cytokine signals, yet how the timing and sequence of these cues …
www.sciencedirect.com
Inherited variations in antibody genes can affect how we respond to infections and vaccines, show two new studies from Karolinska Institutet published in the journal Immunity. The researchers have map...
Inducing broadly neutralizing antibodies (bnAbs) remains a challenge in HIV vaccine
development. Mishra et al. show that an engineered germline-targeting HIV trimer,
Q23-APEX-GT2, primes rare V2-apex ...
