Y. Eva Tan Professor in Neurotechnology, MIT. Mindspan Institute, co-founder. Neuroscientist, inventor, entrepreneur.
Ed Boyden
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It was fun writing this essay, about bottom-up neuroscience and how we might simulate entire brains, using data collected via new technologies (expansion microscopy, optogenetics, whole brain voltage imaging, and more), with @kordinglab.bsky.social!
In a new blog (uniconq.substack.com), Denisa Lepǎdatu and I propose a playful, and perhaps useful, framing of fundamental science that goes for the ground truth - namely, as universe conquering, the confrontation of the foundational unknowns and challenges of existence.
We are hiring a lab manager, for our research group, the Synthetic Neurobiology group (aka Boyden Lab) at MIT/HHMI (on the MIT campus, Cambridge, MA)! Please apply if you're qualified and interested, and spread the word! hhmi.wd1.myworkdayjobs.com/External/job...
Just posted, "The Tiling Tree Method, Part 2: Common Pitfalls and How to Overcome Them" a follow-up to our previous essay on the "tiling tree" method for thinking of all the possible solutions to a problem, by Claire Wang, Nina Khera, and myself. engineeringx.substack.com/p/the-tiling...
Applying new tools to entire brains, starting with C. elegans, offers the opportunity to uncover how molecules work together to generate neural physiology, and how neurons generate behavior, write @kordinglab.bsky.social and @eboyden3.bsky.social.
#neuroskyence
bit.ly/48EzEO8
Diatoms – microscopic algae found almost everywhere there’s water – make up ~25% of Earth’s annual oxygen production.🌎
EMBL researchers have now found a way to easily reveal their inner structures by combining cryo-fixation with ultrastructural expansion microscopy 🔬
www.cell.com/current-biol...
Amid a tumultuous year, researchers opined on policy changes, funding uncertainty, scientific trends and AI’s impact. Read essays by @tuthill.bsky.social, @bingbrunton.bsky.social, @kordinglab.bsky.social, @eboyden3.bsky.social, @docbecca.bsky.social, and Tim Requarth.
#neuroskyence
bit.ly/44NL9jy
New preprint out!
www.biorxiv.org/content/10.6...
One of the most salient lessons I learned in all my adventures with screening and protein engineering is the importance of context. The context in which you test a gene or protein determines what function it has.
Ed Boyden
What if we could locate, sequence, and identify every protein in a cell? This would unlock a transformative way to study biology and disease.
That question shaped my PhD, and I’m excited to share our new preprint on the Principles of In Situ Protein Sequencing, now live on bioRxiv.
Ed Boyden
Throughout a tumultuous year in science, researchers opined on policy changes and funding uncertainty, as well as scientific trends and the impact of artificial-intelligence tools on the field.
I’m so excited to share my first-author PhD paper, out today in Neuron as a NeuroResource! A huge thanks to all of my co-authors, and of course to my wonderful mentors Guoping Feng, @fennak.bsky.social and @eboyden3.bsky.social. www.cell.com/neuron/fullt...
shaharbrr.bsky.social
Camille Mitchell-Wang
A blog about how to overcome the limits of human existence, through ground truth-oriented understanding. Click to read Universe Conquering, a Substack publication. Launched 12 days ago.
Applying new tools to entire brains, starting with C. elegans, offers the opportunity to uncover how molecules work together to generate neural physiology and how neurons work together to generate…
Applying new tools to entire brains, starting with C. elegans, offers the opportunity to uncover how molecules work together to generate neural physiology, and how neurons generate behavior, write @kordinglab.bsky.social and @eboyden3.bsky.social.
#neuroskyence
bit.ly/48EzEO8
Primary Work Address: 77 Massachusetts Avenue, Cambridge, MA, 02139 Current HHMI Employees, click here to apply via your Workday account. The Synthetic Neurobiology Group (Boyden Lab) at the MIT McGov...
Principles of in situ protein sequencing: expansion microscopy-adapted Edman degradation and amino acid recognition https://www.biorxiv.org/content/10.64898/2026.01.29.702630v1
Library transgenesis in zebrafish through delayed site-specific mosaic integration for in vivo pooled screening of transgenes https://www.biorxiv.org/content/10.64898/2026.01.30.702415v1
In this NeuroResource, Schroeder et al. present a transcriptomic atlas across brain
regions and developmental time points in mouse and marmoset. Detailed analysis focused
on astrocytes revealed that t...
