What might the future of deep brain stimulation look like?
Not just continuous stimulation, but decoding symptoms in real time and directing stimulation to the right brain circuits.
Fascinating perspective article by @andreashorn.org & @julianneumann.bsky.social in @natrevneurol.nature.com:
New @netstim.org publication alert: @bahnebahners.bsky.social in BRAIN out now:
academic.oup.com/brain/advanc...
A 🧵:
A bit later, Leon Sobesky & @lukasgoede.bsky.social confirmed that the same is true for *pallidal* DBS. Here as well, electrodes that stimulate this exact PD response network would profit maximally from DBS.
pubmed.ncbi.nlm.nih.gov/34453827/
With SPARK-DBS, @savirmadan.bsky.social adds a new tool to the ecosystem of Lead-DBS: The small-scale databasing tool can store, analyze and integrate stimulation parameters and scores in BIDS-compliant fashion. Toward standardized data analysis in DBS!
www.sciencedirect.com/science/arti...
Bahners et al. identify a brain network linked to optimal therapeutic outcomes in patients with Parkinson’s disease receiving deep brain stimulation. This
Is there a shared brain circuit target for tremor that transcends diagnosis and DBS site? New work by @lukasgoede.bsky.social @andreashorn.org @braincircuits.bsky.social says YES
Tremor is highly heterogeneous. Our new study in @cp-cellreports.bsky.social shows that rest and action tremor map to different networks within the motor cortex. By refining DBS contact selection, we can engage these circuits to optimize treatment for both.
www.cell.com/cell-reports...
In #DeepBrainStimulation
the two major developments across the last decade have been
1. Adaptive DBS and
2. Connectomic DBS
In a @natrevneurol.nature.com article with @julianneumann.bsky.social, we ask:
Could the two be united into a common framework?
www.nature.com/articles/s41...
A 🧵
Goede et al. show that different tremor types engage distinct regions of the motor
cortex. Using deep brain stimulation network mapping, they find that optimal treatment
of rest tremor involves effect...
Tremor is a common symptom across many neurological disorders.
But is there a shared tremor circuit across disorders - one that could guide treatment, regardless of diagnosis?
We think: yes.
Our study is out now in @natcomms.nature.com:
🔗 www.nature.com/articles/s41...
🧵 A thread.
