AAA+ protein unfoldases—the Moirai of the proteome - Azinas - FEBS Letters - Wiley Online Library febs.onlinelibrary.wiley.com/doi/10.1002/...
dave dougan
An N-degron proteolytic pathway modulates recipient susceptibility to T6SS DNase effectors
mtHsp70 chaperone converts mitochondrial proteostasis stress into impaired protein import | PNAS www.pnas.org/doi/full/10....
www.nature.com/articles/s41...
The N-degron pathway regulates glucose and insulin homeostasis through the lysosomal degradation of RXRA/RXRα via SQSTM1/p62: Autophagy: www.tandfonline.com/doi/abs/10.1...
A C-degron regulates Chk1 kinase by allowing stability of inactive Chk1 and by making it short- lived upon activation www.pnas.org/doi/10.1073/...
Activation mechanism and structural assembly of the Mycobacterium tuberculosis ClpP1P2 protease and its associated ATPases: Cell Reports www.cell.com/cell-reports...
A dynamic gateway: Uncovering the expanded human TOM complex interactome and its regulatory complexity | Science Advances www.science.org/doi/10.1126/...
dave dougan
dave dougan
See my new post on our homepage ✍️
The journey to our newest publication on how plants cope with proteotoxic stress ♻️
www.cell.com/molecular-ce...
From Doubt to Discovery: A 15-Year Journey into Proteostasis, Pathogens, and Persistence
More than 15 years ago, during my PhD, we stumbled upon something unexpected. In a yeast two-hybrid screen, bacterial effector proteins from Xanthomonas and Pseudomonas interacted with a subunit of…
theustunlab.com
Insane. This could happen to any of us and in fact, it already has. Scientists need to stand together more visibly and raise their voices collectively. It cannot become normal that entire labs are shut down and scientific work is undermined.
Şuayb Üstün
Şuayb Üstün
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo-electron microscopy (cryo-EM) structures and single-molecule bioph...
Central to the pathogenesis of type 2 diabetes (T2D) is the failure in insulin secretion from pancreatic β-cells associated with insulin resistance. The nuclear receptor RXRA/RXRα (retinoid X recep...
Transcriptional regulation is a central mechanism underlying bacterial adaptation to stress. Here, the authors used a genetic fitness screen to show that the Y-complex in Bacillus subtilis contributes...
Weinhäupl et al. determine the cryo-EM structure of the ClpC1P1P2 complex from Mycobacterium
tuberculosis, revealing an asymmetric architecture and selective activator binding.
They show that molecula...
www.cell.com
The Arg/N-degron pathway of Saccharomyces cerevisiae is mediated by two interacting
E3 ubiquitin ligases, Ubr1 and Ufd4. We show here that the mito...
Breaking news: Indiana University plant microbiologist Roger Innes has been locked out of his laboratory by the school in response to a request by one of his federal funders. The move comes after Innes complained about the government’s prosecution of Chinese postdocs. https://scim.ag/4tsDqRr
Move comes after Roger Innes complained about the government’s prosecution of Chinese postdocs
