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Postoctoring in🇨🇭@ivanagasic.bsky.social Lab Cell biologist #Cytoskeleton & #Microscopy enthusiast 🔬🧫
Ana Coelho Almeida
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Can’t wait for the BioMatter Meeting in beautiful Arolla 🇨🇭⛰️ Amazing lineup of speakers + cutting-edge science on cytoskeleton dynamics from cells to tissues. See you there!
Heading to #CellBio2025 @ascbiology.bsky.social @embo.org? Stop by my poster P0101 tomorrow (Sun, 12:45 PM) in the session “Cytoskeleton and Motility-Microtubule Organization and Dynamics”. Looking forward to lively discussions on tubulin regulation & microtubule organization. See you in Philly!
10mo
(3/5) Tubulin autoregulation is essential for spheroid architecture & viability. Without it: - cells detach (corona forms) - cell death increases 📌This phenotype isn’t due to cell cycle defects or migration — it reflects impaired cell adhesion.
(2/5) Loss or mutation of TTC5, the key mediator of tubulin autoregulation, increases tubulin mRNA and protein levels in 3D spheroids. This leads to microtubule hyperstability and reorganization of the network. 📌Tubulin levels matter (even in steady state!)