Lecturer in Biophysics at King's College London.
Previously Sir Henry Wellcome Fellow with @pcusachs at IBEC Barcelona.
Amy Beedle
🧵🧬 How cells decide when to react could shape future treatments for cancer and fibrosis
A recent study from IBEC and King’s College London reveals a surprising insight: cells don’t just detect mechanical forces, they also measure how long those forces last before reacting.
My postdoc work with @pcusachs.bsky.social is finally out! We find that fibrillar adhesions play an important role regulating the timescales of nuclear mechanotransduction. You can read all about it here : www.nature.com/articles/s41563-026-02590-x
Huge thanks to everyone involved!!
Nuclear deformation and mechano-signalling are regulated by the coupling of vimentin cytoskeleton to the extracellular matrix through fibrillar adhesions, modulating the timescale of mechanotransducti...
