New benchmark by @tclavel.bsky.social & @treichelnicole.bsky.social reveals that while 0.5 Gb works for profiling, de novo MAG assembly requires >10 Gb. Crucially, they found that only 55-82% of high-quality MAGs accurately represented original strains.
Full Article: doi.org/10.1038/s415...
A comparison of sequencing of complex mock communities performed at multiple depths and analysed using different methods establishes minimum standards that can ensure the accuracy of metagenomic analy...
