We present VIPR, a phage-encoded RNA-guided system that recognizes DNA with a noncontiguous code unlike CRISPR.
Tiny, programmable, possibly ancestral to CRISPR immunity; VIPR is built around a striking RNA-DNA-DNA triplex.
Brilliant talk from @kashishsingh.bsky.social at Dynamic Cell VI highlighting their work examining cytoplasmic lattices in embryos using cryo-ET. We highlighted this work in our recent preprint list.
Preprint: www.biorxiv.org/content/10.6...
Preprint list: focalplane.biologists.com/2026/04/17/m...
Cytoplasmic lattices are a highly abundant and essential structure in mouse oocytes and embryos. Our in situ structure from early mouse embryos provides a new insight into their molecular achitecture and function. Check it out: www.biorxiv.org/content/10.6...
Really exciting to see our new review published!
This review explores the evolutionary history of the extra-embryonic endoderm, an evolutionarily ancient tissue co-opted to form the yolk sac, and explores how in vitro models are uncovering its biology.
Check it out here: doi.org/10.1242/dev....
We are hiring POSTDOC now!🚨please repost! Fully-funded 5-year position 👩🏻🔬👨🔬🧬Looking forward to your application!✉️
Doudna Lab
FocalPlane
We're hiring! 🔬🏔️ Looking for curious, open-minded, and multidisciplinary #PhD candidates to research at the intersection of #mitochondria, #metabolism, #imaging & #physiology, with the #Alps as a backdrop. Sounds like you or someone you know? Link below!
@fbm-unil.bsky.social @unil.bsky.social
Ina
www.biorxiv.org
Summary: This Review examines the evolutionary history of the extra-embryonic endoderm, an evolutionarily ancient tissue co-opted to form the yolk sac, and explores how in vitro models are uncovering ...
Excited to share our discovery of a new programmable RNA-guided DNA-targeting system hiding inside bacteriophages that predates CRISPR.
We call it VIPR (Viral Interference Programmable Repeat), and it uses an entirely new logic to find its targets.
Thread + link below.
Video
Niakan Lab
New preprint from the lab, looking at how multiple different adaptors interact with dynein! Work led by @amicoennio.bsky.social.
Available now on BioRxiv: doi.org/10.64898/202...
Takashi Akera Lab
Juan C. Landoni
Excited to share our work on the structure and function of cytoplasmic lattices within mouse embryos. A collaborative effort with @niakanlab.bsky.social and work led by @kashishsingh.bsky.social and @inaharasimov.bsky.social . It is now out on BioRxiv: www.biorxiv.org/content/10.6...
Excited to share our work on the structure and function of cytoplasmic lattices within mouse embryos. A collaborative effort with @niakanlab.bsky.social and work led by @kashishsingh.bsky.social and @inaharasimov.bsky.social . It is now out on BioRxiv: www.biorxiv.org/content/10.6...
The hidden rules behind mRNA transport.
A collaborative study between @simonbullock11.bsky.social & @carter-lab.bsky.social’s groups has found a structural code that explains how cells selectively transport mRNAs.
Read more: mrclmb.ac.uk/news-events/...
#LMBNews @cellbiol-mrclmb.bsky.social 🧪
doi.org
Video
Merriam-Webster
Kenneth Loi
Video
Carter Lab
Carter Lab
Carter Lab
focalplane.biologists.com
MRC Laboratory of Molecular Biology
New preprint! We asked a simple question:
How do very different activating adaptors all activate dynein?
Turns out: same architecture, wildly different implementations 🧵👇
doi.org/10.64898/202...
The Landoni Lab opens this summer at UNIL! @fbm-unil.bsky.social 🔬 Quantitative #imaging + systems biology to decipher how #metabolic architecture & #mtDNA dynamically shape tissue development, #aging and #mitodisease. Beyond excited to fire up the lasers, open positions soon! 🧪 #mitochondria #newPI
