Neuroscientist at UCSF.
Studies everything related to neuronal ion channels—their modulation, their role in neuronal integration, and the intersection between these functions and neurodevelopmental and neuropsychiatric disorders.
Kevin Bender
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How I feel teaching first year grad students every fall… (you have to watch it to understand).
Decent EPSC, but they really need to fix their amplifier gain.
New work from @danfeldman.bsky.social's lab, exploring sensory representations in Scn2a loss of function mice. Whisker representations are blurred, akin to cortical visual impairment often seen in SCN2A kiddos. Rescuable w/ @nadavahituv.bsky.social's CRISPRa @P30!
www.biorxiv.org/content/10.6...
Fresh off the press! @selinsch.bsky.social discovered some really cool features of mouse frontal cortex pyramidal cells that co-vary with dopamine receptor expression. D3R+ cells appear very responsive to AP bursts, producing Ca transients across dendritic arbors.
www.jneurosci.org/content/earl...
Congrats to Margaret Cunniff for, IMHO, leading the Hurricanes to the Stanley Cup! Margaret received her PhD in Neurosci from UCSF, doing awesome work with @vikaassohal.bsky.social. She's one of the first to "moneyball" hockey; looks like it worked!
www.sloansportsconference.com/event/of-mic...
Not posting that much lately, because... well, yeah.
But i have to share this text i got from my daughter. I totally see it.
Patch clampers: we got an error 52 on our Leica vibracheck and the normal "blow on it like a nintendo in the 80s" fix didn't work. Nor did a cleaning of the LED and diode. LED does shine. Has anyone else had such an issue and managed to resurrect this very simple but stupidly expensive thing?
New work from Josh Garcia in our lab! This is a collaboration with David Hackos (formerly Genentech) Roy Ben-Shalom (UC Davis) and Al George (Northwestern) where we use fancy knockin mice to allow for selective block of different sodium channels, revealing their unique roles in excitability.
@pjenkinslab.bsky.social and I wrote a review on the axon initial segment. We tried our best to discuss the state of the field and provide our perspective (and resolution for) some current sticking points. Hope it's useful!
doi.org/10.1152/phys...
SCN2A loss is strongly linked to neurodevelopmental delays and, at times, seizure. In an amazing collaboration with @nadavahituv.bsky.social, led by Serena Tamura, Andrew Nelson, and Perry Spratt, we leveraged CRISPR activator approaches to rescue this loss.
rdcu.be/eGU0W
