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Special to see this paper out from my former lab: >10 years in the making. Lots of striking results! www.nature.com/articles/s41...
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In mice, a circuit between the spinal cord and various regions of the brain, centring on spinal-cord-projecting neurons in the rostral ventromedial medulla, has a key role in driving chronic pain.
www.nature.com
Deconstruction of a spino-brain–spinal cord circuit that drives chronic pain - Nature
Chen Ran